Daniel S. Fierer, MD, is Professor of Medicine and Infectious Diseases at the Icahn School of Medicine at Mount Sinai. In 2006, his group at Mount Sinai recognized the apparent sexual acquisition of hepatitis C virus (HCV) in men who have sex with men (MSM). In response, he developed the first prospective cohort of early HCV infection in MSM in the US through collaboration with over 50 providers of primary care to people with HIV infection in New York City. Through this cohort, and in collaborations with investigators and public health authorities in the US, Europe, and Australia, he has worked to characterize this previously occult pandemic. He has led the field in defining the mechanisms of transmission, the epidemiology, and the pathogenesis of liver disease, as well as advancing the treatment of early infection and promoting early detection and universal treatment, ultimately to improve the lives of people who acquire HCV infection.