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Advances in Anal Cancer Prevention in People with HIV


Published Date: 03/11/2024

Expiration Date: 02/19/2027

CE Credit: CME:1


PRN has long supported efforts to prevent the devastating outcomes of anal cancer in people living with HIV (PLWH). Much progress has been made through the success of the ANCHOR Study which was ended ahead of schedule due to the indisputably favorable outcomes for people receiving treatment for pre-cancerous anal lesions. This confirmation of proactive efforts to destroy high-grade squamous intraepithelial lesions in and around the anus using high-resolution anoscopy emphasizes the role that we in HIV primary care must routinely incorporate into our care for all PLWH. In this program, Dr. Joel Palefsky, the principal investigator of the ANCHOR Study, will update us on the most recent guidelines for anal cancer prevention.


Joel Palefsky,M.D., C.M., F.R.C.P.(C)

Joel Palefsky, M.D., C.M., F.R.C.P.(C). Professor of Medicine and Infectious Diseases at the University of California San Francisco School of Medicine. He trained in medicine and Internal Medicine at McGill University in Montreal Canada and in Infectious Diseases at Stanford University. He is an internationally recognized expert on the molecular biology, treatment, pathogenesis and natural history of anogenital human papillomavirus infections, particularly in the setting of HIV infection. He is the founder and director of the world's first clinic devoted to prevention of anal cancer, the Anal Neoplasia Clinic Research and Education Center at the UCSF Cancer Center. He is the vice-chair of the National Cancer Institute (NCI)-supported AIDS Malignancy Consortium. He is the chair of the Anal Cancer /HSIL Outcomes Research (ANCHOR) Study, a national multi-site NIH study that showed that treatment of anal cancer precursor lesions prevents the development of anal cancer. He is founder and past president of the International Anal Neoplasia Society and is past president of the International Papillomavirus Society. He is founder and director of the International Papillomavirus Society International HPV Awareness campaign.

Learning Objectives

  • Understand the current epidemiology of anal cancer in people living with HIV
  • Be aware of the results of the ANCHOR study
  • Be aware of HPV vaccination recommendations and new screening guidelines for anal cancer prevention in people living with HIV
  • Understand gaps in knowledge in screening and treatment of anal high-grade squamous intraepithelial lesions

Continuing Education Credit Information